Author

M. K. Kuhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. A. Proctor· 3 shared R. M. Fleeman· 2 shared A. C. Arnold· 1 shared A. M. Snyder· 1 shared C. D. Barrett· 1 shared D. A. Lauffenburger· 1 shared D. C. Chan· 1 shared D. K. Brubaker· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPhysiology

E. A. Proctor

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3 papers

Recent·Most cited

Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ϵ4 mice

R. M. Fleeman, A. M. Snyder, M. K. Kuhn, D. C. Chan, G. C. Smith, N. A. Crowley, A. C. Arnold, E. A. Proctor

This study identifies a predictive link between systemic metabolism and cytokine signatures in the brain of APOE4 mice, showing APOE genotype-dependent differences in aging mice.

bioRxiv · Feb 11, 2022Physiology

GM1 mediates the formation and maintenance of cytotoxic Aβ oligomers

D. Zhang, J. Wang, R. M. Fleeman, M. K. Kuhn, M. T. Swulius, E. A. Proctor, N. V. Dokholyan

This study shows GM1 promotes Aβ oligomer formation and maintains their stability on membranes, supporting the Aβ ion channel hypothesis and highlighting GM1 as a target for Alzheimer's disease research.

bioRxiv · Jul 22, 2021 · PreprintBiophysics

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

E. A. Proctor, S. M. Dineen, S. C. Van Nostrand, M. K. Kuhn, C. D. Barrett, D. K. Brubaker, M. B. Yaffe, D. A. Lauffenburger, L. R. Leon

The paper identifies a coagulopathy signature in a mouse heat stroke model that predicts severity and precedes organ damage.

bioRxiv · Sep 18, 2019Physiology