D. A. Lauffenburger

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma

The paper identifies novel IL13Rα2-targeted CARs with improved anti-glioblastoma efficacy using a pooled screening platform.

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guerin vaccination in rhesus macaques

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

An affinity for brainstem microglia in pediatric high grade gliomas of brainstem origin

This study identifies IL33 as a factor promoting DIPG proliferation in the brainstem microenvironment, highlighting its role in the spatiotemporal pattern of pediatric high-grade gliomas.

Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles

This study compares the Fc-functional antibody profiles of mRNA-1273 and BNT162b2 vaccines in a cohort of hospital staff, finding differences in epitope-specific responses and effector functions.

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Collateral Responses to Classical Cytotoxic Chemotherapies are Heterogeneous and Sensitivities are Sparse

The paper examines collateral responses to four classical chemotherapy agents and finds no collateral sensitivities but observes phenotypic heterogeneity unrelated to transcriptomic heterogeneity.

COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women

This study examines how mRNA vaccines affect Fc-functional antibody profiles in pregnant, lactating, and non-pregnant women, finding delayed kinetics and altered immune responses in pregnant and lactating individuals.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

This study uses a novel immunopeptidomics approach to quantify MHC I repertoire changes induced by CDK4/6 inhibition and interferon gamma in melanoma.

Pancreatic Stellate Cells Secrete Deoxycytidine Conferring Resistance to Gemcitabine in PDAC

This study shows that pancreatic stellate cells secrete deoxycytidine, which reduces the effectiveness of gemcitabine in PDAC by inhibiting its processing in cancer cells.

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

The paper identifies a coagulopathy signature in a mouse heat stroke model that predicts severity and precedes organ damage.

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.