Author

M. K. Manik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Assay:proteomics· 1

Frequent Co-Authors

B. Kobe· 2 shared L. Song· 2 shared M. Grant· 2 shared S. Li· 2 shared T. Ve· 2 shared A. DiAntonio· 1 shared A. M. Bayless· 1 shared B. Y. Lim· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPlant Biology

B. Kobe

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2 papers

Recent·Most cited

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

A. M. Bayless, S. Chen, S. C. Ogden, X. Xu, J. D. Sidda, M. K. Manik, S. Li, B. Kobe, T. Ve, L. Song, M. Grant, L. Wan, M. T. Nishimura

This study investigates whether prokaryotic Thoeris TIRs can cross-activate plant TIR-immunity and finds they generate overlapping cADPR isomers but have distinct signaling requirements.

bioRxiv · Sep 19, 2022Plant Biology

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

M. K. Manik, Y. Shi, S. Li, M. A. Zaydman, N. Damaraju, S. Eastman, T. Smith, W. Gu, V. Masic, T. Mosaiab, J. S. Weagley, S. J. Hancock, E. Vasquez, L. Hartley-Tassell, N. Maruta, , B. Kobe

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

bioRxiv · May 7, 2022 · PreprintBiochemistry