Author

M. Klaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

M. Grininger· 3 shared A. D. D'Souza· 1 shared A. Nivina· 1 shared A.-K. Thebille· 1 shared C. F. Krebs· 1 shared C. Khosla· 1 shared C. Kuppe· 1 shared E. Hoxha· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

M. Grininger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deep learning-based molecular morphometrics for kidney biopsies

M. Zimmermann, M. Klaus, M. N. Wong, A.-K. Thebille, L. Gernhold, C. Kuppe, M. Halder, J. Kranz, N. Wanner, F. Braun, S. Wulf, T. Wiech, U. Panzer, C. F. Krebs, E. Hoxha, , V. G. Puelles

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

bioRxiv · Aug 23, 2020Pathology

The Ketosynthase Domain Constrains the Design of Polyketide Synthases

M. Klaus, L. Buyachuihan, M. Grininger

This study identifies bottlenecks in chimeric modular PKSs and proposes guidelines for improving their efficiency through targeted mutations in the ketosynthase domain.

bioRxiv · Jan 23, 2020Biochemistry

Engineering of chimeric polyketide synthases using SYNZIP docking domains

M. Klaus, A. D. D'Souza, A. Nivina, C. Khosla, M. Grininger

This study compares chimeric PKSs with different interfaces to identify the least invasive method for PKS engineering, showing that SYNZIP domains can effectively replace natural docking domains.

bioRxiv · Dec 7, 2018Biochemistry

Analysis and Engineering of Substrate Shuttling by the Acyl Carrier Protein (ACP) in Fatty Acid Synthases (FASs)

E. Rossini, J. Gajewski, M. Klaus, G. Hummer, M. Grininger

This study assesses how domain-domain interactions affect fatty acid synthesis by mutating interfaces in FASs and measuring product spectra and enzyme activity.

bioRxiv · Jul 18, 2018Bioengineering