M. Zimmermann

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

Systematic analysis of gut bacterial carcinogen metabolism and its functional consequences

The paper systematically analyzes gut bacterial metabolism of carcinogens and shows bidirectional interactions with host metabolism, highlighting the microbiome's role in tumorigenesis.

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.

Podocyte exopher-formation as a novel pathomechanism in membranous nephropathy

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.

Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants

This study reveals interindividual variability in gut microbial metabolism of immunosuppressive drugs mediated by specific bacterial species and enzymes.

Pervasive sublethal effects of agrochemicals as contributing factors to insect decline

This study shows sublethal agrochemical exposure harms insect behavior, survival, and reproduction, with effects amplified by temperature changes, contributing to insect population decline.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

This study identifies genetic alterations that enhance the efficacy of ATR and PARP inhibitor combinations while reducing toxicity through CRISPR screens and mechanistic analysis.

Entrectinib - a SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells

This study identifies entrectinib as a potential antiviral drug against SARS-CoV-2 using drug repurposing, virtual screening, and in vitro assays in Human Lung Tissue cells.

Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

This study dynamically analyzes sugar metabolism to uncover how synthetic sugar analogs are metabolized and their effects on cellular pathways.

Deep learning-based molecular morphometrics for kidney biopsies

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

Binding of the motor protein SecA to the bacterial protein translocation channel SecYEG in the absence of ATP

The paper investigates how SecA remains bound to SecYEG without ATP, showing stable interactions and conformational changes that support protein translocation.

A genetic map of the response to DNA damage in human cells

The paper identifies 840 genes involved in the DNA damage response through CRISPR/Cas9 screens and highlights specific gene functions in DNA repair and toxicity mechanisms.

Growth and rapid succession of methanotrophs effectively limit methane release during lake overturn

The paper shows that methanotrophs in a mixing lake undergo a bloom and succession, oxidizing most stored methane during lake overturn, thus limiting methane release.

Lake overturn as a key driver for methane oxidation

The paper quantifies methane oxidation in lakes during overturn periods, showing that microbial activity and physical conditions determine methane flux and emissions.

Ammonia inhibits energy metabolism in astrocytes in a rapid and GDH2-dependent manner

The paper shows ammonia inhibits astrocyte energy metabolism via GDH2-dependent mechanisms, disrupting mitochondrial respiration and the TCA cycle under hyperammonemia.

Host metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation

This study shows that phage LUZ19 modulates Pseudomonas aeruginosa quorum sensing by expressing Qst, which interacts with PqsD to reduce PQS metabolites, enabling successful infection.

Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response

The paper develops a model to distinguish microbial and host metabolites using stable isotope tracing and shows that antibodies limit microbial metabolite penetration into host tissues.