A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA
M. Kolesnichenko, N. Mikuda, U. E. Höpken, M. Milanovic, A. B. Tufan, B. Uyar, W. Sun, K. Schleich, L. von Hoff, M. Willenbrock, I. Krahn, S. Jungmann, M. Hinz, A. Akalin, S. Lee, , C. Scheidereit
The paper identifies a novel IKK- and proteasome-independent mechanism of RelA activation in senescent cells that drives the senescence-associated secretome through transcriptional repression of NFKBIA.
bioRxiv · Dec 19, 2019Cell Biology