Author

M. Kovalova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Perina· 2 shared R. Jorda· 2 shared D. Kurfurstova· 1 shared E. Frank· 1 shared E. Reznickova· 1 shared E. Szczyrbova· 1 shared G. Motyan· 1 shared J. Bouchal· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

M. Perina

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Characterization of new highly selective pyrazolopyrimidine inhibitor of CDK7

M. Kovalova, L. Havlicek, S. Djukic, J. Skerlova, M. Perina, T. Pospisil, E. Reznickova, P. Rezacova, R. Jorda, V. Krystof

This paper characterizes a new CDK7 inhibitor, LGR6768, showing nanomolar potency and selectivity, with structural and cellular evidence supporting its mechanism and therapeutic potential.

bioRxiv · Feb 24, 2023Cancer Biology

A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor

M. Perina, M. A. Kiss, G. Motyan, E. Szczyrbova, M. Elias, V. Student, D. Kurfurstova, M. Kovalova, L. Mada, J. Bouchal, E. Frank, R. Jorda

This paper synthesizes and evaluates A-ring-fused pyrazoles derived from dihydrotestosterone as AR antagonists with antiproliferative activity in prostate cancer cells.

bioRxiv · Dec 17, 2022Pharmacology & Toxicology

Effect of simulated microgravity on gene expression during embryogenesis of Arabidopsis thaliana

M. Svecerova, M. Kovalova, V. Ondrej

This study examines how simulated microgravity affects gene expression in Arabidopsis thaliana embryos, finding increased expression in several genes related to stress response and development.

bioRxiv · Nov 14, 2018 · PreprintPlant Biology