A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function
N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden
The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.
bioRxiv · Feb 21, 2019 · PreprintCell Biology