O. Rozenblatt-Rosen

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

A cellular and spatial atlas of TP53-associated tissue remodeling in lung adenocarcinoma

This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

Pan-cancer mapping of single T cell profiles reveals a TCF1:CXCR6-CXCL16 regulatory axis essential for effective anti-tumor immunity

The paper identifies a TCF1:CXCR6-CXCL16 regulatory axis critical for anti-tumor immunity by analyzing single-cell RNA-seq data from multiple cancers.

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity

This study uses scRNA-seq and snRNA-seq to analyze 73,295 human liver cells, revealing heterogeneity in hepatic stellate cells, cholangiocytes, and interzonal hepatocytes.

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

The paper identifies IL-33 as a driver of tumor immunosuppression by analyzing longitudinal single-cell RNA-Seq data of regulatory T cells in a mouse model of lung adenocarcinoma.