Author

N. Baryawno

Karolinska Institutet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Cell Biology· 1 Immunology· 1

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Organism:human· 7 Research Focus:cell type annotation· 6 Assay:scRNA-seq· 6 Approach:experimental assay· 5 Research Focus:cell-cell communication· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:mouse· 3

Frequent Co-Authors

P. V. Kharchenko· 4 shared S. Mei· 4 shared Y. Kfoury· 4 shared D. B. Sykes· 3 shared D. Scadden· 3 shared J. I. Johnsen· 3 shared N. Severe· 3 shared P. Kogner· 3 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCancer Biology

P. V. Kharchenko

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Author profile →

9 papers

Recent·Most cited

Circadian gene-network distortion in high-risk neuroblastoma across multiple biological reference contexts

N Maussier, Dimitrios Tsagkogiannis, N. Baryawno, Per Kogner, John Inge Johnsen, Malin Wickström, Cecilia H. Dyberg, Oscar C. Bedoya-Reina, Tomas Sjöberg Bexelius

This study identifies circadian gene network disruption in high-risk neuroblastoma across multiple biological contexts, showing it is a network-level alteration rather than a single-gene effect.

bioRxiv · Sep 29, 2026 · PreprintCancer Biology

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

A. M. Alchahin, S. Mei, I. Tsea, T. Hirz, Y. Kfoury, D. Dahl, C.-L. Wu, A. O. Subtelny, S. Wu, D. T. Scadden, J. H. Shin, P. J. Saylor, D. B. Sykes, P. V. Kharchenko, N. Baryawno

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

bioRxiv · Jun 28, 2022Cancer Biology

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

T. Hirz, S. Mei, H. Sarkar, Y. Kfoury, S. Wu, B. M. Verhoeven, A. O. Subtelny, D. V. Zlatev, M. W. Wszolek, K. Salari, E. Murray, F. Chen, E. Z. Macosko, C.-L. Wu, D. T. Scadden, , D. B. Sykes

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

T. K. Olsen, C. Dyberg, B. Embaie, A. Alchahin, J. Milosevic, J. Otte, C. Tummler, I. H. Myrberg, E. M. Westerhout, J. Koster, R. Versteeg, P. Kogner, J. I. Johnsen, D. B. Sykes, N. Baryawno

This study identifies DHODH as a prognostic marker and therapeutic target in neuroblastoma, showing its inhibition improves survival in preclinical models and suggests combination therapy with temozolomide.

bioRxiv · Sep 25, 2021Cancer Biology

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

J. Milosevic, S. Fransson, M. Gulyas, G. Gallo-Oller, T. K. Olsen, D. Treis, M. Wickstrom, L. H. Elfman, B. Sveinbjornsson, F. Hertwig, C. Bartenhagen, S. Reinsbach, M. Wilhelm, F. Abel, N. Javanmardi, , P. Kogner

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

T. K. Olsen, J. Otte, S. Mei, P. Kameneva, A. Bjoerklund, E. Kryukov, Z. Hou, A. Johansson, E. Sundstroem, T. Martinsson, S. Fransson, J. I. Johnsen, P. Kogner, I. Adameyko, P. V. Kharchenko, N. Baryawno

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

bioRxiv · May 4, 2020 · PreprintCancer Biology

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

N. Baryawno, Y. Kfoury, N. Severe, S. Mei, K. U. Gustafsson, T. Hirz, T. Brouse, E. Scadden, B. Choi, N. Barkas, J. Shin, P. Saylor, D. Scadden, D. Sykes, P. Kharchenko

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

bioRxiv · Feb 21, 2019 · PreprintCell Biology