Author

P. Gonzalo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

I. Mikaelian· 2 shared A. Barkaway· 1 shared A. G. Arroyo· 1 shared A. Gil-Ordonez· 1 shared A. Sahun-Espanol· 1 shared B. Allais· 1 shared B. Marcos-Ramiro· 1 shared C. Anjard· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

I. Mikaelian

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

L. Jabbour, T. Nguyen, R. Gadet, O. Lohez, I. Mikaelian, P. Gonzalo, T. Luyten, M. Chalabi, G. Bultynck, R. Rimokh, G. Gillet, N. Popgeorgiev

This study shows that Bcl-xL at the endoplasmic reticulum (ER) dampens the unfolded protein response (UPR) by reducing IP3R-mediated calcium release, thereby preventing ER calcium depletion and cell death.

bioRxiv · Jan 27, 2021 · PreprintCell Biology

Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

O. Cochet-Escartin, M. Demircigil, S. Hirose, B. Allais, P. Gonzalo, I. Mikaelian, V. Calvez, K. Funamoto, C. Anjard, J.-P. Rieu

This study shows that Dictyostelium discoideum exhibits aerotactic migration under hypoxia, forming a dense ring through cell division and aerotaxis without cell-cell communication.

bioRxiv · Aug 17, 2020Biophysics

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ after myocardial infarction

L. Alonso-Herranz, A. Sahun-Espanol, P. Gonzalo, P. Gkontra, V. Nunez, M. Cedenilla, M. Villalba-Orero, J. Inserte, C. Clemente, D. Garcia-Dorado, A. G. Arroyo, M. Ricote

This study shows that macrophage MT1-MMP promotes EndMT in cardiac endothelial cells after MI, contributing to fibrosis and adverse remodeling, and identifies it as a potential therapeutic target.

bioRxiv · Aug 7, 2020Immunology

Isoprenylcysteine carboxylmethyltransferase basedtherapy for Hutchinson Gilford progeria syndrome

B. Marcos-Ramiro, A. Gil-Ordonez, N. I. Marin-Ramos, F. J. Ortega-Nogales, M. Balabasquer, P. Gonzalo, L. Rolas, A. Barkaway, S. Nourshargh, V. Andres, M. Martin-Fontecha, M. L. Lopez-Rodriguez, S. Ortega-Gutierrez

This study develops UCM-13207, an ICMT inhibitor that reduces progerin nuclear accumulation and improves phenotypes in progeria models.

bioRxiv · Jul 23, 2020Pharmacology & Toxicology