Author

M. Laggner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Copic· 4 shared H. J. Ankersmit· 4 shared M. Mildner· 4 shared D. Bormann· 3 shared K. Klas· 3 shared M. Direder· 3 shared A. Mangold· 1 shared A. S. Ondracek· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersImmunology

D. Copic

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antithymocyte globulin inhibits CD8+ T cell effector functions via the paracrine induction of PDL-1 on monocytes

D. Copic, M. Direder, K. Klas, D. Bormann, M. Laggner, H. J. Ankersmit, M. Mildner

ATG increases PDL-1 on CD14+ monocytes and inhibits T cell effector functions.

bioRxiv · Jul 26, 2022Immunology

The effect of paracrine factors released by irradiated peripheral blood mononuclear cells on neutrophil extracellular trap formation

K. Klas, A. S. Ondracek, T. M. Hofbauer, A. Mangold, K. Pfisterer, M. Laggner, D. Copic, M. Direder, D. Bormann, H. J. Ankersmit, M. Mildner

This study shows that secretome from stressed PBMCs inhibits NET formation by reducing ROS, upregulating antioxidant proteins, and inhibiting PAD4 activation.

bioRxiv · May 30, 2022 · PreprintImmunology

Paracrine factors of stressed peripheral blood mononuclear cells activate pro-angiogenic and anti- proteolytic processes in whole blood cells and protect the endothelial barrier

D. Copic, M. Direder, K. Schossleitner, M. Laggner, K. Klas, D. Bormann, H. J. Ankersmit, M. Mildner

This study shows that paracrine factors from gamma-irradiated PBMCs alter gene expression in blood cells and protect endothelial barriers, suggesting potential therapeutic use in tissue repair.

bioRxiv · Apr 22, 2022 · PreprintCell Biology

Single cell landscape of hypertrophic scars identifies serine proteases as key regulators of myofibroblast differentiation

V. Vorstandlechner, M. Laggner, D. Copic, Y. Chen, B. Golabi, W. Haslik, C. Radtke, E. Tschachler, H. J. Ankersmit, M. Mildner

The paper uses single-cell sequencing to analyze hypertrophic scars, identifying serine proteases as key regulators of myofibroblast differentiation and suggesting their inhibition for treating skin fibrosis.

bioRxiv · Jun 17, 2020 · PreprintCell Biology