Proliferation impairs cell viability via energy depletion
P. Galichon, M. Lannoy, L. Li, S. Vandermeersch, D. Legouis, M. T. Valerius, J. Hadchouel, J. V. Bonventre
The paper shows that proliferation in kidney cells reduces energy availability, leading to cell death and chronic kidney disease under metabolic stress.
bioRxiv · Apr 24, 2020 · PreprintPhysiology