Author

M. Ledda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Pluchino· 2 shared M. Ragusa· 2 shared A. Gaigneaux· 1 shared A. Kiriazis· 1 shared C. Heffelfinger· 1 shared D. D. A. Pincot· 1 shared D. K. Abankwa· 1 shared D. Runcie· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersEvolutionary Biology

A. Pluchino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unraveling Evolutionary Dynamics: Insights from In Silico Experiments on Selective Mechanisms in Controlled Environments

M. Ledda, A. Pluchino, M. Ragusa

The paper uses in silico experiments to analyze selective mechanisms in controlled environments, showing how evolutionary dynamics can be modeled and understood through population genetics and the Price equation.

bioRxiv · Oct 24, 2023 · PreprintEvolutionary Biology

An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

P. Kaya, E. Schaffner-Reckinger, G. B. Manoharan, V. Vukic, A. Kiriazis, M. Ledda, M. Burgos, K. Pavic, A. Gaigneaux, E. Glaab, D. K. Abankwa

The paper develops a novel PDE6D inhibitor, Deltaflexin3, which synergizes with Sildenafil to inhibit KRAS mutant cancer cell growth, though survival data suggest further exploration of K-Ras and PDE6D interplay.

bioRxiv · Aug 23, 2023Biochemistry

Colorectal cancer as a Model for Biological Evolution

M. Ledda, A. Pluchino, M. Ragusa

This paper presents an agent-based model to simulate tumor progression in a colonic crypt, aiming to test lab results and explore alternative tumor development scenarios.

bioRxiv · Apr 13, 2023 · PreprintCancer Biology

Social Network Analysis of the Genealogy of Strawberry: Retracing the Wild Roots of Heirloom and Modern Cultivars

D. D. A. Pincot, M. Ledda, M. Feldmann, M. A. Hardigan, T. J. Poorten, D. Runcie, C. Heffelfinger, S. L. Dellaporta, G. S. Cole, S. J. Knapp

This paper reconstructs the genealogy of cultivated strawberry to uncover its complex hybrid ancestry and domestication history, revealing key ancestral contributions and changes in breeding cycles.

bioRxiv · Sep 30, 2020Plant Biology