Author

A. Gaigneaux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. K. Abankwa· 2 shared G. b. Manoharan· 2 shared K. Pavic· 2 shared A. Badkas· 1 shared A. Hemedan· 1 shared A. Kiriazis· 1 shared A. Muller· 1 shared A. Yeste-Vazquez· 1 shared

Activity by Year

2023-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

D. K. Abankwa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The gut microbiome-linked long chain fatty acid stearate suppresses colorectal cancer

M. Tsenkova, M. Brauer, V. Pozdeev, M. Kasakin, S. B. Busi, M. Schmoetten, D. Cheung, M. Meyers, F. Rodriguez, A. Gaigneaux, E. Koncina, C. Gilson, L. Schlicker, D. Herebian, M. Schmitz, , E. Letellier

This study shows that the ketogenic diet reduces colorectal tumors in mice by altering the gut microbiome to increase stearic acid, which suppresses cancer cell growth and immune responses.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

Identification of an H-Ras nanocluster disrupting peptide

G. b. Manoharan, C. L. Steffen, K. Pavic, A. Yeste-Vazquez, M. Knuuttila, N. Arora, Y. Zhou, H. Harma, A. Gaigneaux, T. N. Grossmann, D. K. Abankwa

The paper identifies a peptide that disrupts the interaction between Gal1 and B-Raf-RBD, reducing H-Ras nanoclustering and MAPK signaling in cancer cells.

bioRxiv · Sep 7, 2023 · PreprintBiochemistry

An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

P. Kaya, E. Schaffner-Reckinger, G. B. Manoharan, V. Vukic, A. Kiriazis, M. Ledda, M. Burgos, K. Pavic, A. Gaigneaux, E. Glaab, D. K. Abankwa

The paper develops a novel PDE6D inhibitor, Deltaflexin3, which synergizes with Sildenafil to inhibit KRAS mutant cancer cell growth, though survival data suggest further exploration of K-Ras and PDE6D interplay.

bioRxiv · Aug 23, 2023Biochemistry

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

V. Gureghian, H. Herbst, I. Kozar, K. Mihajlovic, N. Malod-Dognin, G. Ceddia, C. Angeli, C. Margue, T. Randic, D. Philippidou, M. Tetsi Nomigni, A. Hemedan, L.-C. Tranchevent, J. Longworth, M. Bauer, , S. Kreis

This study identifies genes and pathways involved in senescence escape in NRAS mutant melanoma using multi-omics approaches.

bioRxiv · Feb 13, 2023Cancer Biology