An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
P. Kaya, E. Schaffner-Reckinger, G. B. Manoharan, V. Vukic, A. Kiriazis, M. Ledda, M. Burgos, K. Pavic, A. Gaigneaux, E. Glaab, D. K. Abankwa
The paper develops a novel PDE6D inhibitor, Deltaflexin3, which synergizes with Sildenafil to inhibit KRAS mutant cancer cell growth, though survival data suggest further exploration of K-Ras and PDE6D interplay.
bioRxiv · Aug 23, 2023Biochemistry