M. Legendre

A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer

This paper demonstrates that the engineered lectin H84T binds to and inhibits NSCLC cell growth by lysosomal degradation of EGFR, independent of EGFR mutation status.

An update on eukaryotic viruses revived from ancient permafrost

The paper reports the isolation and characterization of 13 new viruses from ancient permafrost samples, highlighting their potential to challenge assumptions about the rarity of revived viruses.

Evolution of giant pandoravirus from small icosahedral viruses revealed by CRISPR/Cas9

The paper uses CRISPR/Cas9 to genetically modify giant viruses and their host, revealing evolutionary transitions from small icosahedral viruses to larger amphora-shaped viruses.

Characterization of Mollivirus kamchatka, the first modern representative of the proposed Molliviridae family of giant viruses

The paper describes the isolation and characterization of Mollivirus kamchatka, a modern relative of M. sibericum, confirming the persistence of molliviruses and their evolutionary relationship with pandoraviruses.

Commensalism in the Mimiviridae giant virus family

This study investigates the interaction network between a virophage, transpovirons, and their host giant viruses, revealing a form of commensalism where transpovirons use virophages to propagate without affecting the host virus's infectious cycle.

Pandoravirus celtis illustrates the microevolution processes at work in the giant Pandoraviridae genomes

The paper analyzes the Pandoravirus celtis genome to test the hypothesis that new protein-coding genes arise de novo from non-coding regions, finding ORFans and transposase insertions.

Diversity and evolution of the emerging Pandoraviridae family

This study analyzes the genomic diversity and evolution of the Pandoraviridae family by comparing newly isolated strains and performing comprehensive annotation.