Author

S. Santini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Assay:whole-genome sequencing· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J.-M. Claverie· 6 shared C. Abergel· 5 shared A. Lartigue· 4 shared J.-M. Alempic· 4 shared M. Legendre· 3 shared A. Le Bivic· 2 shared A. N. Fedorov· 2 shared C. Borchiellini· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersMicrobiology

J.-M. Claverie

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Author profile →

8 papers

Recent·Most cited

Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes

J.-M. Alempic, H. Bisio, A. Villalta, S. Santini, A. Lartigue, A. Schmitt, C. Bugnot, A. Notaro, L. BELMUDES, A. Adrait, O. Poirot, D. Ptchelkine, C. De Castro, Y. Coute, C. Abergel

The study shows that deleting GMC-oxidoreductase genes in mimiviruses does not impair genomic fiber or fibril layer formation, indicating functional redundancy.

bioRxiv · Apr 28, 2023Microbiology

An update on eukaryotic viruses revived from ancient permafrost

J.-M. Alempic, A. Lartigue, A. E. Goncharov, G. Grosse, J. Strauss, A. N. Tikhonov, A. N. Fedorov, O. Poirot, M. Legendre, S. Santini, C. Abergel, J.-M. Claverie

The paper reports the isolation and characterization of 13 new viruses from ancient permafrost samples, highlighting their potential to challenge assumptions about the rarity of revived viruses.

bioRxiv · Nov 10, 2022Microbiology

The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes

S. Santini, Q. Schenkelaars, C. Jourda, M. Duschene, H. Belahbib, C. Rocher, M. Selva, A. Riesgo, M. Vervoort, S. P. Leys, L. Kodjabachian, A. Le Bivic, C. Borchiellini, J.-M. Claverie, E. Renard

This study analyzes the genome of the glass sponge Oopsacas minuta, revealing its compact size and loss of key metazoan genes, suggesting unique evolutionary adaptations.

bioRxiv · Jul 26, 2022 · PreprintEvolutionary Biology

One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.

F. Petragnano, I. Fasciani, Z. Wang, R. Edwards, N. Telugu, I. Pietrantoni, U. Zabel, H. Zauber, M. Grieben, M. E. Terzenidou, J. Di Gregorio, C. Pellegrini, S. Santini, A. R. Taddei, B. Poehl, , R. Maggio

The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.

bioRxiv · Apr 13, 2021Cell Biology

High prevalence and diversity of beta-lactamase-encoding bacteria in cryosoils and ancient permafrost

S. Rigou, E. Christo-Foroux, S. Santini, A. Goncharov, J. Strauss, G. Grosse, A. N. Fedorov, K. Labadie, C. Abergel, J.-M. Claverie

This study identifies a high prevalence of beta-lactamase-encoding bacteria in Arctic and subarctic soils and permafrost, suggesting global warming could mobilize ancient DNA and contribute to antibiotic resistance.

bioRxiv · Mar 17, 2021Microbiology

Characterization of Mollivirus kamchatka, the first modern representative of the proposed Molliviridae family of giant viruses

E. Christo-Foroux, J.-M. Alempic, A. Lartigue, S. Santini, K. Labadie, M. Legendre, C. Abergel, J.-M. Claverie

The paper describes the isolation and characterization of Mollivirus kamchatka, a modern relative of M. sibericum, confirming the persistence of molliviruses and their evolutionary relationship with pandoraviruses.

Journal of Virology · Mar 31, 2020Peer-reviewedMicrobiology

Commensalism in the Mimiviridae giant virus family

S. Jeudy, L. Bertaux, J.-M. Alempic, A. Lartigue, M. Legendre, L. Belmudes, S. Santini, N. Philippe, L. Beucher, E. G. Biondi, S. Juul, D. J. Turner, Y. Coute, J.-M. Claverie, C. Abergel

This study investigates the interaction network between a virophage, transpovirons, and their host giant viruses, revealing a form of commensalism where transpovirons use virophages to propagate without affecting the host virus's infectious cycle.

bioRxiv · Sep 25, 2019 · PreprintMicrobiology

NEW GENOMIC DATA AND ANALYSES CHALLENGE THE TRADITIONAL VISION OF ANIMAL EPITHELIUM EVOLUTION

H. Belahbib, E. Renard, S. Santini, C. Jourda, J.-M. Claverie, C. Borchiellini, A. Le Bivic

This study challenges the traditional view of animal epithelium evolution by comparing genomic and transcriptomic data across sponges, placozoans, and ctenophores, revealing divergent or absent epithelial markers in ctenophores.

bioRxiv · Dec 4, 2017Evolutionary Biology