Author

M. Lepore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Paleontology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Altieri· 1 shared A. Beshirova· 1 shared A. C. Kalli· 1 shared A. Chancellor· 1 shared A. Cohnen· 1 shared A. Hottinger· 1 shared A. O'Dea· 1 shared A. Vacchini· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPaleontology

A. Altieri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells

A. Vacchini, A. Chancellor, Q. Yang, J. Spagnuolo, D. Joss, O. Oyas, A. Beshirova, C. De Gregorio, M. Pfeffer, J. Stelling, D. Häussinger, M. Lepore, L. Mori, G. De Libero

The paper identifies nucleobase adduct-containing metabolites as MR1 ligands that activate self-reactive MR1T cells, highlighting their role in detecting metabolic stress in cancer.

bioRxiv · Aug 26, 2022 · PreprintImmunology

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

C. Cudalbu, P. Bady, M. Lai, L. Xin, O. Gusyatiner, M.-F. Hamou, M. Lepore, J.-P. Brouland, R. T. Daniel, A. Hottinger, M. E. Hegi

This study compares metabolic and transcriptomic profiles of glioblastoma in patient tumors and orthotopic xenografts in mice to identify invasion-related molecular signatures.

Acta Neuropathologica Communications · Aug 4, 2021Peer-reviewedCancer Biology

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

A.-L. Lanz, G. Masi, N. Porciello, A. Cohnen, D. Cipria, D. Prakaash, S. Balint, R. Raggiaschi, D. Galgano, D. Cole, M. Lepore, O. Dushek, M. Dustin, M. Sansom, A. C. Kalli, O. Acuto

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

bioRxiv · Dec 2, 2020Immunology

Defining variation in pre-human ecosystems can guide conservation: An example from a Caribbean coral reef

A. O'Dea, M. Lepore, A. Altieri, M. Chan, J. Morales, N.-H. Munoz, J. Pandolfi, M. Toscano, J.-x. Zhao, E. Dillon

This study defines historical variation in Caribbean coral reefs using fossil records to show that most modern reefs are in novel states, while one reef has remained stable for over 760 years.

bioRxiv · Aug 29, 2019Paleontology