Author

A.-L. Lanz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Cipria· 2 shared G. Masi· 2 shared N. Porciello· 2 shared O. Acuto· 2 shared A. C. Kalli· 1 shared A. Cohnen· 1 shared A. Grottesi· 1 shared D. Cole· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

D. Cipria

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2 papers

Recent·Most cited

A role of Lck annular lipids in the steady upkeep of active Lck in T cells

N. Porciello, D. Cipria, G. Masi, A.-L. Lanz, E. Milanetti, A. Grottesi, D. Howie, S. P. Cobbold, L. Schermelleh, M. D'Abramo, H.-T. He, N. Destainville, O. Acuto, K. Nika

The paper investigates how annular lipids affect Lck kinase activity in T cells by examining the balance between autophosphorylation and dephosphorylation by CD45.

bioRxiv · Mar 18, 2022 · PreprintCell Biology

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

A.-L. Lanz, G. Masi, N. Porciello, A. Cohnen, D. Cipria, D. Prakaash, S. Balint, R. Raggiaschi, D. Galgano, D. Cole, M. Lepore, O. Dushek, M. Dustin, M. Sansom, A. C. Kalli, O. Acuto

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

bioRxiv · Dec 2, 2020Immunology