Author

M. Losby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

C. Billon· 2 shared L. Zhang· 2 shared M. Hayes· 2 shared T. Burris· 2 shared A. Graves· 1 shared A. Milosavljevic· 1 shared A. Valfort· 1 shared C. Fu· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

C. Billon

Mutual co-authors in cluster

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2 papers

Recent·Most cited

The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB

M. Losby, M. Hayes, A. Valfort, J. Walker, W. L. Xu, L. Zhang, C. Billon, T. Burris

This study identifies ERRs as regulators of autophagy through TFEB activation in cardiomyocytes, suggesting ERR targeting as a therapeutic strategy for heart failure.

bioRxiv · Mar 2, 2023Cell Biology

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

W. Xu, C. Billon, H. Li, M. Hayes, K. Yu, M. Losby, C. S. Hampton, C. M. Adeyemi, A. Graves, E. Nasiotis, C. Fu, R. Welch, R. M. Evans, L. Pei, J. K. Walker, , L. Zhang

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

bioRxiv · Feb 14, 2022 · PreprintPharmacology & Toxicology