Author

J. K. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

C. Billon· 2 shared C. M. Adeyemi· 2 shared L. Zhang· 2 shared M. Hayes· 2 shared R. Welch· 2 shared T. Burris· 2 shared W. Xu· 2 shared A. Chatterjee· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Billon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Predicting Permeation of Compounds across the Outer Membrane of P. aeruginosa Using Molecular Descriptors: Advantages and Limitations

P. D. Manrique, I. Leus, C. A. Lopez, J. Mehla, G. Malloci, S. Gervasoni, A. Vargiu, R. Kinthada, L. Herndon, N. Hengartner, J. K. Walker, V. Rybenkov, P. Ruggerone, H. Zgurskaya, S. Gnanakaran

This study identifies molecular descriptors predictive of compound permeation across P. aeruginosa outer membrane using physicochemical, docking, and MD simulation data.

bioRxiv · Sep 2, 2023 · PreprintBiophysics

A Synthetic ERRα Agonist Induces an Acute AerobicExercise Response and Enhances Exercise Capacity

C. Billon, S. Banerjee, S. Situala, R. Welch, L. Hegazy, B. Elgendy, T. G. Oh, M. Kazantzis, A. Chatterjee, J. Chrivia, M. Hayes, W. Xu, A. Hamilton, J. Huss, L. Zhang, , T. Burris

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

bioRxiv · Oct 5, 2022 · PreprintPharmacology & Toxicology

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

W. Xu, C. Billon, H. Li, M. Hayes, K. Yu, M. Losby, C. S. Hampton, C. M. Adeyemi, A. Graves, E. Nasiotis, C. Fu, R. Welch, R. M. Evans, L. Pei, J. K. Walker, , L. Zhang

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

bioRxiv · Feb 14, 2022 · PreprintPharmacology & Toxicology

A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2

K. B. Tsegay, C. M. Adeyemi, E. P. Gniffke, D. N. E. P. Sather, J. K. Walker, S. E. P. Smith

The paper screens 2701 approved drugs to find those inhibiting SARS-CoV-2 spike protein binding to ACE2, identifying 56 compounds with >90% inhibition and modeling their docking.

bioRxiv · Apr 8, 2021Pharmacology & Toxicology