Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation
G. Zhao, M. E. Gentile, L. Xue, C. V. Cosgriff, A. I. Weiner, S. Adams-Tzivelekidis, J. Wong, X. Li, S. Kass-Gergi, N. P. Holcomb, M. C. Basil, K. M. Steward, J. D. Planer, E. Cantu, J. D. Christi, , A. E. Vaughan
This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.
Nature Communications · May 18, 2024Peer-reviewedImmunology