Author

M. E. Gentile

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. E. Vaughan· 2 shared N. P. Holcomb· 2 shared A. Gregorieff· 1 shared A. I. Weiner· 1 shared A. Jaquish· 1 shared A. Rochette· 1 shared C. V. Cosgriff· 1 shared D. Karo-Atar· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

A. E. Vaughan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

G. Zhao, M. E. Gentile, L. Xue, C. V. Cosgriff, A. I. Weiner, S. Adams-Tzivelekidis, J. Wong, X. Li, S. Kass-Gergi, N. P. Holcomb, M. C. Basil, K. M. Steward, J. D. Planer, E. Cantu, J. D. Christi, , A. E. Vaughan

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Nature Communications · May 18, 2024Peer-reviewedImmunology

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

J. Barr, M. E. Gentile, S. Lee, M. Kotas, M. Fernanda de Mello Costa, N. P. Holcomb, A. Jaquish, G. Palashikar, I. Matsumoto, R. Margolskee, N. A. Cohen, X. Sun, A. E. Vaughan

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

bioRxiv · Mar 10, 2022Cell Biology

Direct reprogramming of the intestinal epithelium by parasitic helminths subverts type 2 immunity

D. Karo-Atar, S. Ouladan, T. Javkar, L. Joumier, M. K. Matheson, S. Merritt, S. Westfall, A. Rochette, M. E. Gentile, G. Fontes, G. J. Fonseca, M. Parisien, L. Diatchenko, J. von Moltke, M. Malleshaiah, , I. L. King

This study shows that helminth infection reprograms intestinal epithelium into a fetal-like state, generating stem cells that inhibit type 2 immunity and promote helminth survival.

bioRxiv · Sep 25, 2021Immunology