Author

A. E. Vaughan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2

Frequent Co-Authors

N. J. Meyer· 3 shared A. Weiner· 2 shared E. Cantu· 2 shared M. C. Basil· 2 shared M. E. Gentile· 2 shared N. P. Holcomb· 2 shared N. S. Mangalmurti· 2 shared X. Li· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

N. J. Meyer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

G. Zhao, M. E. Gentile, L. Xue, C. V. Cosgriff, A. I. Weiner, S. Adams-Tzivelekidis, J. Wong, X. Li, S. Kass-Gergi, N. P. Holcomb, M. C. Basil, K. M. Steward, J. D. Planer, E. Cantu, J. D. Christi, , A. E. Vaughan

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Nature Communications · May 18, 2024Peer-reviewedImmunology

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

D. L. Jones, M. P. Morley, X. Li, Y. Yun, F. L. Cardenas-Diaz, S. Li, S. Zhou, S. E. Schaefer, U. V. Chembazhi, A. Nottingham, S. Lin, E. Cantu, J. M. Diamond, M. C. Basil, A. E. Vaughan, E. E. Morrisey

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

bioRxiv · Feb 26, 2024 · PreprintCell Biology

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

J. Barr, M. E. Gentile, S. Lee, M. Kotas, M. Fernanda de Mello Costa, N. P. Holcomb, A. Jaquish, G. Palashikar, I. Matsumoto, R. Margolskee, N. A. Cohen, X. Sun, A. E. Vaughan

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

bioRxiv · Mar 10, 2022Cell Biology

Human red blood cells express the RNA sensor TLR7 and bind viral RNA

L. M. Lam, R. L. Clements, K. A. Eckart, A. R. Weisman, A. E. Vaughan, N. Yehya, N. J. Meyer, K. A. Jurado, N. S. Mangalmurti

This study shows human red blood cells express TLR7 and bind viral RNA, suggesting a potential role in immune responses and RNA-based diagnostics.

bioRxiv · Jan 1, 2022 · PreprintImmunology

Microstructured hydrogels to guide self-assembly and function of lung alveolospheres

C. Loebel, A. Weiner, J. Katzen, M. Morley, V. Bala, F. Cardenas-Diaz, M. Davidson, K. Shiraishi, M. Basil, M. Ochs, M. Beers, E. Morrisey, A. E. Vaughan, J. Burdick

This paper introduces a hydrogel-based method to culture lung alveolospheres without Matrigel, reducing heterogeneity while maintaining cell fate.

bioRxiv · Aug 30, 2021Bioengineering

Red Blood Cells Function as DNA Sensors

M. Lam, S. Murphy, D. Kokkinaki, A. Venosa, S. Sherrill-Mix, C. Casu, S. Rivella, A. Weiner, J. Park, S. Shin, A. E. Vaughan, B. H. Hahn, A. R. Odom John, N. J. Meyer, C. A. Hunter, , N. S. Mangalmurti

The paper shows red blood cells detect and bind DNA, triggering immune responses during infections.

bioRxiv · Feb 11, 2021 · PreprintImmunology