Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.
M. M. Kuijk, Y. Wu, V. P. van Hensbergen, G. Shanlitourk, C. Payre, G. Lambeau, J. Herrmann, R. Müller, J. A. G. van Strijp, Y. Pannekoek, L. Touqui, N. M. van Sorge
This study identifies LspA as a key factor in hGIIA resistance in MRSA and shows that inhibiting LspA increases susceptibility to hGIIA and daptomycin.
bioRxiv · Feb 6, 2022 · PreprintMicrobiology