Author

R. Müller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 7 Microbiology· 4 Physiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 11 Organism:mouse· 7 Assay:imaging· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:clustering· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

G. A. Kuhn· 6 shared E. Wehrle· 4 shared A. C. Scheuren· 2 shared C. J. Collins· 2 shared F. C. Marques· 2 shared G. R. Paul· 2 shared J. Herrmann· 2 shared M. Blauth· 2 shared

Activity by Year

2020-2022 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBioengineering

G. A. Kuhn

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-based in silico model using single-cell mechanomics

D. Boaretti, F. C. Marques, C. Ledoux, A. Singh, J. J. Kendall, E. Wehrle, G. A. Kuhn, Y. D. Bansod, F. Schulte, R. Müller

This paper develops an in silico model of trabecular bone remodeling in aging mice, showing how changes in OPG, RANKL, and Scl levels affect bone volume fraction.

bioRxiv · Nov 16, 2022 · PreprintBioengineering

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

J. R. Sullivan, J. Yao, C. Courtine, A. Lupien, J. Herrmann, R. Müller, M. A. Behr

bioRxiv · Jun 27, 2022Microbiology

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.

M. M. Kuijk, Y. Wu, V. P. van Hensbergen, G. Shanlitourk, C. Payre, G. Lambeau, J. Herrmann, R. Müller, J. A. G. van Strijp, Y. Pannekoek, L. Touqui, N. M. van Sorge

This study identifies LspA as a key factor in hGIIA resistance in MRSA and shows that inhibiting LspA increases susceptibility to hGIIA and daptomycin.

bioRxiv · Feb 6, 2022 · PreprintMicrobiology

Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

M. Scherer, C. Read, G. Neusser, C. Kranz, R. Müller, F. Full, S. Woerz, A. Reichel, E.-M. Schilling, P. Walther, T. Stamminger

The paper shows that dual interferon and DNA damage signaling leads to the formation of giant PML nuclear bodies that trap viral genomes and capsids, providing a multilayered antiviral defense.

bioRxiv · Aug 24, 2021Microbiology

Bone mechanoregulation allows subject-specific load estimation based on time-lapsed micro-CT and HR-pQCT in vivo

M. Walle, F. C. Marques, N. Ohs, M. Blauth, R. Müller, C. J. Collins

This paper develops a mechanoregulation-based load estimation algorithm (MR) to improve the accuracy of in vivo bone loading estimation using time-lapsed micro-CT and HR-pQCT data, outperforming existing methods in synthetic and clinical datasets.

bioRxiv · Feb 22, 2021Bioengineering

Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography

E. Goff, F. Buccino, C. Bregoli, J. P. McKinley, B. Aeppli, R. R. Recker, E. Shane, A. Cohen, G. Kuhn, R. Müller

This study assesses the accuracy, reproducibility, and sensitivity of ultra-high-resolution desktop micro-CT for large-scale quantification of human osteocyte lacunar morphometry in clinical biopsies.

bioRxiv · Jan 5, 2021Bioengineering

Sesbanimide R, a novel cytotoxic polyketide produced by magnetotactic bacteria

R. P. Awal, P. A. Haack, C. D. Bader, C. N. Riese, D. Schüler, R. Müller

This study identifies sesbanimide R, a novel cytotoxic polyketide from magnetotactic bacteria, revealing its structure and biosynthesis pathway and demonstrating its cytotoxic activity against carcinoma cell lines.

bioRxiv · Dec 22, 2020Microbiology

The Behavior of Molecular Measures of Natural Selection after a Change in Population Size.

R. Müller, I. Kaj, C. F. Mugal

The paper examines how molecular measures of natural selection respond to population size changes, finding that microevolutionary measures react quickly but lose information rapidly, while macroevolutionary measures respond more slowly but retain ancient information.

bioRxiv · Dec 18, 2020Evolutionary Biology

Automated Segmentation of Fractured Distal Radii by 3D Geodesic Active Contouring of in vivo HR-pQCT Images

N. Ohs, C. J. Collins, D. C. Tourolle, P. R. Atkins, B. Schroeder, M. Blauth, P. Christen, R. Müller

This paper introduces a 3D-GAC method for automated segmentation of fractured distal radii from HR-pQCT images, showing high accuracy and robustness compared to manual contouring.

bioRxiv · Oct 14, 2020Bioengineering

Longitudinal in vivo micro-CT-based approach allows spatio-temporal characterization of fracture healing patterns and assessment of biomaterials in mouse femur defect models

E. Wehrle, D. C. Tourolle né Betts, G. A. Kuhn, E. Floreani, M. H. Nambiar, B. J. Schroeder, S. Hofmann, R. Müller

This study uses longitudinal in vivo micro-CT to analyze fracture healing and assess biomaterials in mouse femur defects, showing collagen scaffolds often fail while BMP-2 improves healing outcomes.

bioRxiv · Oct 2, 2020 · PreprintBioengineering

Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging

E. Wehrle, G. R. Paul, D. C. Tourolle ne Betts, G. A. Kuhn, R. Müller

This study shows that individualized cyclic mechanical loading during the remodelling phase of fracture healing in mice increases callus formation and mineralization through effects on Wnt-signalling targets.

bioRxiv · Sep 15, 2020Bioengineering

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

A. Malhotra, M. Walle, G. R. Paul, G. A. Kuhn, R. Müller

This study uses real-time finite element analysis to apply adaptive mechanical loading to improve bone healing in a mouse vertebral defect model.

bioRxiv · Sep 13, 2020 · PreprintBioengineering

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice

A. C. Scheuren, G. A. Kuhn, R. Müller

This study assesses the impact of long-term in vivo micro-CT imaging on aging markers in mice, finding small but significant changes in bone morphology without genotype-specific effects.

bioRxiv · May 10, 2020Physiology

Hallmarks of frailty and osteosarcopenia in prematurely aged PolgAD257A/D257A mice

A. C. Scheuren, G. D'Hulst, G. A. Kuhn, E. Masschelein, E. Wehrle, K. De Bock, R. Müller

This study evaluates PolgA(D257A/D257A) mice as a model for frailty and osteosarcopenia, showing accelerated health deficits and musculoskeletal deterioration compared to wild-type mice.

bioRxiv · Feb 14, 2020Physiology