Author

N. M. van Sorge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 13 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Organism:human· 10 Research Focus:host-pathogen & immune response· 8 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Organism:bacteria (other)· 3 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

G. Lambeau· 4 shared V. P. van Hensbergen· 4 shared C. Payre· 3 shared J. S. Rush· 3 shared K. V. Korotkov· 3 shared N. Korotkova· 3 shared Y. Pannekoek· 3 shared A. Hendriks· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

G. Lambeau

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Author profile →

14 papers

Recent·Most cited

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

A. Hendriks, P. F. Kerkman, M. R. Varkila, J. L. Haitsma-Mulier, S. Ali, T. ten Doesschate, T. W. van der Vaart, C. J. C. de Haas, P. C. Aerts, O. L. Cremer, M. J. Bonten, V. Nizet, G. Y. Liu, J. D. C. Codee, S. H. Rooijakkers, , N. M. van Sorge

This study identifies WTA-specific IgM as a critical immune factor for human protection against S. aureus, outperforming IgG in opsonophagocytic activity and correlating with clinical outcomes.

bioRxiv · Jul 14, 2023 · PreprintMicrobiology

Novel emm4 lineage associated with an upsurge in invasive group A streptococcal disease in the Netherlands, 2022

B. C. van der Putten, W. C. Bril-Keijzers, L. W. Rumke, S. M. T. Vestjens, L. A. Koster, M. Willemsen, M. A. van Houten, N. Y. Rots, B. J. M. Vlaminckx, B. de Gier, N. M. van Sorge

The paper identifies a novel emm4 lineage, M4NL22, as the cause of an increase in invasive group A streptococcal disease in the Netherlands in 2022.

bioRxiv · Dec 31, 2022 · PreprintMicrobiology

Neisseria meningitidis sibling small regulatory RNAs connect metabolism with colonization by controlling propionate use.

S. Man-Bovenkerk, K. Schipper, N. M. van Sorge, D. Speijer, A. van der Ende, Y. Pannekoek

This study identifies NmsRs as small regulatory RNAs that control propionate metabolism in Neisseria meningitidis, linking metabolic state to colonization of the nasopharynx.

bioRxiv · Nov 13, 2022 · PreprintMicrobiology

Genetic diversity of Staphylococcus aureus wall teichoic acid glycosyltransferases affects immune recognition

S. M. Tamminga, S. L. Völpel, K. Schipper, T. Stehle, Y. Pannekoek, N. M. van Sorge

The paper analyzes the genetic diversity of three WTA glycosyltransferases in S. aureus and shows their impact on immune recognition through functional assays.

bioRxiv · May 25, 2022Microbiology

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A2 and daptomycin.

M. M. Kuijk, Y. Wu, V. P. van Hensbergen, G. Shanlitourk, C. Payre, G. Lambeau, J. Herrmann, R. Müller, J. A. G. van Strijp, Y. Pannekoek, L. Touqui, N. M. van Sorge

This study identifies LspA as a key factor in hGIIA resistance in MRSA and shows that inhibiting LspA increases susceptibility to hGIIA and daptomycin.

bioRxiv · Feb 6, 2022 · PreprintMicrobiology

The impact of Staphylococcus aureus cell wall glycosylation on langerin recognition and Langerhans cell activation

A. Hendriks, R. van Dalen, S. Ali, D. Gerlach, G. A. van der Marel, F. F. Fuchsberger, P. Aerts, C. J. C. de Haas, A. Peschel, C. Rademacher, J. van Strijp, J. D. Codee, N. M. van Sorge

This study investigates how different glycosylation patterns on Staphylococcus aureus cell walls affect langerin recognition and Langerhans cell activation, finding that β-GlcNAc is sufficient for langerin binding regardless of its position on WTA.

bioRxiv · Nov 6, 2020Microbiology

Modification of cell wall polysaccharide spatially controls cell division in Streptococcus mutans

S. Zamakhaeva, C. T. Chaton, J. S. Rush, S. Ajay Castro, A. E. Yarawsky, A. B. Herr, N. M. van Sorge, H. C. Dorfmueller, G. I. Frolenkov, K. V. Korotkov, N. Korotkova

This study shows that GroP-deficient immature SCCs spatially coordinate AtlA and MapZ localization in S. mutans, ensuring proper cell division and morphology.

bioRxiv · Jun 26, 2020Microbiology

Bacterial protein domains with a novel Ig-like fold bind human CEACAM receptors

N. M. van Sorge, D. A. Bonsor, L. Deng, E. Lindahl, V. Schmitt, M. Lyndin, A. Schmidt, O. R. Nilsson, J. Brizuela, E. Boero, E. J. Sundberg, J. van Strijp, K. S. Doran, B. S. Singer, G. Lindahl, A. J. McCarthy

This study identifies a novel Ig-like fold in bacterial adhesins that binds human CEACAM receptors, suggesting a broad mechanism for bacterial pathogenesis.

bioRxiv · Jun 9, 2020Microbiology

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

D. A. C. Heesterbeek, R. M. Muts, V. P. van Hensbergen, P. de Saint Aulaire, T. Wennekes, B. W. Bardoel, N. M. van Sorge, S. H. M. Rooijakkers

This study shows how MAC pores in Gram-negative bacteria's outer membrane make them more susceptible to immune system components like lysozyme and phospholipases, enhancing bacterial clearance.

bioRxiv · Jan 28, 2020Immunology

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

R. J. Edgar, V. P. van Hensbergen, A. Ruda, A. G. Turner, P. Deng, Y. Le Breton, N. M. El-Sayed, A. T. Belew, K. S. McIver, A. G. McEwan, A. J. Morris, G. Lambeau, M. J. Walker, J. S. Rush, K. V. Korotkov, , N. Korotkova

The paper identifies a glycerol phosphate modification on streptococcal rhamnose polysaccharides, revealing its role in host-pathogen interactions and vaccine design.

bioRxiv · Jan 27, 2019Microbiology

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects

V. P. van Hensbergen, E. Movert, V. de Maat, C. Luechtenborg, Y. Le Breton, G. Lambeau, C. Payre, A. Henningham, V. Nizet, J. A. G. Van Strijp, B. Bruegger, F. Carlsson, K. S. McIver, N. M. van Sorge

This study identifies Lancefield polysaccharides as critical for hGIIA to kill Group A and B Streptococcus by enabling penetration through the bacterial cell wall.

bioRxiv · Aug 16, 2018Microbiology

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification

S. L. van der Beek, A. Zorzoli, E. Canak, R. N. Chapman, B. H. Meyer, G.-J. P. H. Boons, H. C. Dorfmueller, N. M. van Sorge

This study functionally characterizes dTDP-L-rhamnose biosynthesis enzymes in Streptococcus pyogenes and identifies Ri03 as a lead compound inhibiting growth of GAS and related pathogens.

bioRxiv · Jun 22, 2018Microbiology

Group IIA secreted phospholipase A2 in human serum kills commensal but not clinical Enterococcus faecium isolates

F. L. Paganelli, H. L. Leavis, S. He, N. M. van Sorge, C. Payre, G. Lambeau, R. J. Willems, S. H. Rooijakkers

The paper shows human serum kills commensal Enterococcus faecium but not clinical isolates, mediated by hGIIA, highlighting a potential mechanism for hGIIA resistance in clinical strains.

bioRxiv · Feb 28, 2018Microbiology

The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A Carbohydrate in Streptococcus pyogenes

J. S. Rush, R. J. Edgar, P. Deng, J. Chen, H. Zhu, N. M. van Sorge, A. J. Morris, K. V. Korotkov, N. Korotkova

bioRxiv · Oct 6, 2017Microbiology