Author

M. M. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Ghosh· 3 shared M. R. Soto· 2 shared R. P. Mohanty· 2 shared Y. Pan· 2 shared E. Y. Maier· 1 shared J. Leal· 1 shared R. F. Alzhrani· 1 shared T. Dong· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBioengineering

D. Ghosh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies

R. P. Mohanty, Y. Pan, M. M. Lewis, M. R. Soto, E. Y. Maier, R. F. Alzhrani, D. Ghosh

Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.

bioRxiv · Dec 22, 2023 · PreprintBioengineering

Applying machine learning to identify ionizable lipids for nanoparticle-mediated delivery of mRNA

M. M. Lewis, T. J. Beck, D. Ghosh

This paper uses machine learning to predict the effectiveness of ionizable lipids for mRNA delivery, identifying the number of outside carbons as a key factor.

bioRxiv · Nov 9, 2023 · PreprintBioengineering

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

M. R. Soto, M. M. Lewis, J. Leal, Y. Pan, R. P. Mohanty, X. Peng, T. Dong, D. Ghosh

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

bioRxiv · Sep 13, 2023 · PreprintBioengineering