The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignment
S. Elowe, L. Gama Braga, C. Landry, A. Cisneros, M. M. Mathieu, P. Thebault, C. Garand, B. Lottin, P. Garcia, M. Clerc
This study shows the BUBR1 pseudokinase domain enhances PP2A-B56 recruitment to kinetochores, ensuring proper checkpoint silencing and chromosome alignment by modulating phosphorylation.
bioRxiv · Aug 13, 2019 · PreprintCell Biology