Semisynthesis reveals Apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse
J. Wyatt, M. Tavassoli, M. M. Mueller
The paper shows that phosphorylation of Apoptin at Thr108 makes it selectively toxic to cancer cells by causing cytoskeletal collapse and cell death.
bioRxiv · Nov 23, 2022Cancer Biology