A dual strategy - in vitro and in silico - to evaluate human antitetanus mAbs addressing their potential protective action on TeNT endocytosis in primary rat neuronal cells
C. P. Lima, G. M. Barreiros, A. S. Oliveira, M. M. Souza, T. M. Manieri, A. M. Moro
This paper evaluates two human monoclonal antibodies against tetanus toxin using in vitro and in silico methods, showing they reduce TeNT internalization in rat neurons by over 50%.
bioRxiv · Feb 25, 2024 · PreprintImmunology