The microbiome mediates subchondral bone loss and metabolomic changes after acute joint trauma
A. K. Hahn, C. W. Wallace, H. D. Welhaven, E. Brooks, M. McAlpione, B. A. Christiansen, S. T. Walk, R. K. June
This study compares the early joint injury responses in germ-free and conventional mice, finding that germ-free mice show less bone loss and distinct metabolic profiles linked to immune regulation.
bioRxiv · May 8, 2020Immunology