R. K. June

Heat Conduction Simulation of Chondrocyte-Embedded Agarose Gels Suggests Negligible Impact of Viscoelastic Dissipation on Temperature Change

The paper measures thermal properties of agarose hydrogels and compares them to articular cartilage, finding similar thermal characteristics.

Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage

This study compares metabolomic profiles of healthy and osteoarthritic human cartilage to identify disease-associated metabolic endotypes and pathways.

Osteochondral fluid transport in an ex vivo system

This study tests diffusion of 3kDa tracers from bone-to-cartilage in bovine osteochondral cores under different loading conditions and finds significant fluid transport with cyclic compression affecting tracer concentration.

Metabolomic Profiling to Identify Early Urinary Biomarkers and Metabolic Pathway Alterations in Autosomal Dominant Polycystic Kidney Disease

This study identifies metabolic pathway alterations and candidate biomarkers in early-stage ADPKD using metabolomic profiling of urine samples.

Metabolomic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid

This study identifies distinct metabolomic profiles in synovial fluid associated with knee injury types and patient sex, suggesting metabolic differences linked to post-traumatic osteoarthritis development.

Correlations between metabolites in the synovial fluid and serum: a mouse injury study

This study compares metabolomic biomarkers in synovial fluid and serum of injured mice to understand early osteoarthritis responses and identify potential biomarkers.

Subchondral bone and synovial fluid metabolomic profiles are altered in injured and contralateral limbs 7 days after non-invasive joint injury in skeletally-mature C57BL/6 mice

This study examines bone and synovial fluid changes 7 days after ACL injury in mice, finding altered bone microarchitecture and distinct metabolic shifts in injured limbs.

The cortical bone metabolome of C57BL/6J mice is sexually dimorphic

The study compares metabolomes of cortical bone, whole bone, and bone marrow in C57BL/6J mice, revealing sex differences and associations with bone strength.

A comparison of shear- and compression-induced mechanotransduction in SW1353 chondrocytes

The paper compares shear- and compression-induced mechanotransduction in SW1353 chondrocytes using metabolomics to identify altered pathways.

Development and analytical validation of a finite element model of fluid transport through osteochondral tissue

The paper develops and validates a finite element model of fluid transport in osteochondral tissue, showing pressure gradients at the cartilage-bone interface during loading.

Metabolomic Profiling and Mechanotransduction of Single Chondrocytes Encapsulated in Alginate Microgels

This study uses alginate microgels to culture single chondrocytes and examines their metabolomic responses to mechanical loading, showing distinct profiles compared to controls.

A 3-D Constitutive Model for Finite Element Analyses of Agarose with a Range of Gel Concentrations

This study develops a 3-D constitutive model for high-stiffness agarose gels to predict intra-gel stresses in cell-seeded constructs, enabling better mechanobiology analysis.

The microbiome mediates subchondral bone loss and metabolomic changes after acute joint trauma

This study compares the early joint injury responses in germ-free and conventional mice, finding that germ-free mice show less bone loss and distinct metabolic profiles linked to immune regulation.

The TAT Protein Transduction Domain as an Intra-articular Drug-Delivery Technology

This study evaluates the TAT peptide transduction domain as a drug delivery method for intra-articular therapies, showing its ability to deliver siRNA and induce genetic recombination in vivo.