A new mechanism of posttranslational polyglutamylation regulates phase separation and signaling of the Wnt pathway protein Dishevelled.
M. Kravec, O. Sedo, J. Nedvedova, M. Micka, M. Sulcova, N. Zezula, K. Gomoryova, D. Potesil, R. S. Ganji, I. Cervenka, Z. Zdrahal, J. Harnos, K. Tripsianes, C. Janke, C. Barinka, V. Bryja
The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.
bioRxiv · Jul 28, 2023 · PreprintCell Biology