Z. Zdrahal

An iPSC-derived bio-inspired scaffold modelling the structure and the effects of extracellular matrix in cardiac fibrosis

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

A new mechanism of posttranslational polyglutamylation regulates phase separation and signaling of the Wnt pathway protein Dishevelled.

The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.

A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis

This study identifies CDKD;3 as a gene that suppresses meiotic defects in smg7 mutants by promoting meiotic exit and enabling cytokinesis in Arabidopsis.

RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion

This study shows RNF43 inhibits WNT5A signaling and suppresses melanoma invasion by ubiquitinating VANGL2 and internalizing ROR1, leading to worse prognosis in RNF43-low patients.

Lyn controls chemotaxis and motility of CLL cells via phosphorylation of ROR1.

This study shows Lyn phosphorylates ROR1, affecting its surface levels and migratory properties in CLL cells, linking BCR and ROR1 signaling.

Primitive RNA-catalysis with guanine-rich oligonucleotide sequences - the case of a (GGC)3 nonamer

The paper investigates the catalytic potential of a (GGC)3 nonamer by showing thermal treatment produces a (GGC)3G species and supports transient geometries compatible with terminal recombination chemistry.

Laser capture microdissection in combination with mass spectrometry: Approach to characterization of tissue-specific proteomes of Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea)

This study uses laser capture microdissection and mass spectrometry to identify tissue-specific proteomes in Eudiplozoon nipponicum, revealing 2,059 proteins and confirming the presence of cathepsin L in the intestine.

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2

This study identifies multiple TTBK2 substrates and their phosphorylation sites, showing their role in ciliogenesis and revealing distinct phosphorylation motifs.

Comparative phosphorylation map of Dishevelled3 (DVL3)

The study compares DVL3 phosphorylation by eight kinases and identifies kinase-specific phosphorylation signatures.