Author

M. Mitchison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Assay:spatial transcriptomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A.-M. Baker· 2 shared C. Kimberley· 2 shared M. Jansen· 2 shared M. Mossner· 2 shared A. Antoniou· 1 shared A. Banerjee· 1 shared A. M. Berner· 1 shared A. Sottoriva· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A.-M. Baker

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Author profile →

2 papers

Recent·Most cited

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

E. Lakatos, V. Gunasri, L. Zapata, J. Househam, T. Heide, N. Trahearn, O. Swinyard, L. Cisneros, C. Lynn, M. Mossner, C. Kimberley, I. Spiteri, G. D. Cresswell, G. Llibre-Palomar, M. Mitchison, , T. A. Graham

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

bioRxiv · Feb 12, 2024 · PreprintCancer Biology

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

W. Cross, S. Nowinski, G. Cresswell, M. Mossner, A. Banerjee, B. Lu, M. Williams, G. Vlachogiannis, L. Gay, A.-M. Baker, C. Kimberley, F. Whiting, H. Belnoue-Davis, P. Martinez, M. Traki, , Wat

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

bioRxiv · Mar 26, 2020 · PreprintCancer Biology