M. Williams

Investigating the Impact of Omental Adipocytes on Ovarian Cancer: Insights from a 3D in-silico model

This study develops a 3D in-silico model to investigate how omental adipocytes influence ovarian cancer progression by simulating the effects of adipose media concentration, treatment dosage, and initial tumour size.

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

Exploring the role of EMT in Ovarian Cancer Progression: Insights from a multiscale mathematical model

This study uses a multiscale mathematical model to explore how EMT influences ovarian cancer progression in two cell lines, finding that EMT and cell cycle parameters significantly affect tumor dynamics.

The effects of genome size on cell size and the functional composition and morphology of leaves: a case study in Rhododendron (Ericaceae)

This study examines how genome size affects cell size, leaf morphology, and resource acquisition in Rhododendron species, finding a tradeoff between CO2 diffusion and water retention.

Ultra-long-acting refillable nanofluidic implant confers full protection against SHIV infection in non-human primates

An ultra-long-acting refillable nanofluidic implant sustained islatravir levels in non-human primates for 20 months and provided 100% protection against SHIV infection.

Logging alters tropical forest structure, while conversion to agriculture reduces biodiversity and functioning

The paper analyzes the impacts of logging and conversion to oil palm on tropical forest structure, biodiversity, and functioning in Borneo, finding that logging affects structure more than biodiversity, while conversion has greater impacts on biodiversity and functioning.

The Children's Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

Evaluating user experience with immersive technology in simulation-based education: a modified Delphi study with qualitative analysis

This study uses a modified Delphi method to identify key domains for measuring user experience with immersive technology in simulation-based education, finding consensus on core domains but not on barriers.

Inactivated SARS-CoV-2 Reprograms the Tumor Immune Microenvironment and Improves Murine Cancer Outcomes

This study shows that inactivated SARS-CoV-2 converts immunologically cold tumors to hot by generating CD8+ T cells, improving cancer outcomes in melanoma and triple-negative breast cancer.

Activation of ChvG-ChvI regulon by cell wall stress confers resistance to β-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens

Transcriptome and DNA methylome dynamics reveal differential characteristics of inflorescence development between two ecotypes in Panicum hallii

A comparative transcriptome and DNA methylome analysis of inflorescence between upland and lowland ecotypes reveals gene expression and DNA methylation variation underlying inflorescence divergence in Panicum hallii.

#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol

This paper uses AI-enabled multiscale computational microscopy to study SARS-CoV-2 Delta variant in respiratory aerosols, revealing atomic-level insights into airborne transmission.

Limited Phylogenetic Overlap Between Fluoroquinolone-Resistant Escherichia coli Isolated on Dairy Farms and those Causing Bacteriuria in Humans Living in the Same Geographical Region

The paper investigates the link between fluoroquinolone-resistant E. coli on dairy farms and human bacteriuria in the same region, finding limited phylogenetic overlap and identifying farm use patterns as risk factors.

Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding

This study shows antidepressants like imipramine and citalopram enhance Lp(a) uptake via serotonin-mediated cell surface binding and PlgRKT receptor upregulation, suggesting potential therapeutic use for lowering Lp(a) in depression patients.

An exceptionally preserved euarthropod with unique feather-like appendages from the Chengjiang biota

The paper describes a new Cambrian euarthropod with unique feather-like appendages, revealing insights into early limb diversity in stem-group euarthropods.

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.

The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.

Using seedling phenotypic traits to select local seed sources for large-scale restoration: methods and outcomes in a Great Basin case study

This study compares wild-collected and commercial seeds of two Great Basin grasses, finding wild seeds have traits beneficial for seedling establishment in restoration sites.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Self-regulation of single-stranded DNA wrapping dynamics by E. coli SSB promotes both stable binding and rapid dissociation

This study shows how E. coli SSB regulates ssDNA binding dynamics through conformational changes, enabling both stable binding and rapid dissociation under varying protein concentrations.

Characterisation of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017-2018.

This study characterizes cefotaxime-resistant urinary E. coli from primary care in South-West England, finding blaCTX-M carriage as the most common resistance mechanism.

A workflow for visualizing human cancer biopsies using large-format electron microscopy

This paper describes a workflow for 2D and 3D imaging of human cancer biopsies using electron microscopy to reveal ultrastructural details not visible with conventional 2D EM.

Anopheles gambiae TEP1 forms a complex with the coiled-coil domain of LRIM1/APL1C following a conformational change in the thioester domain

This paper investigates how allelic variation in TEP1 affects its stability and interaction with LRIM1/APL1C, revealing that conformational changes regulate complex formation and immune function in Anopheles gambiae.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

Speed breeding: a powerful tool to accelerate crop research and breeding

This paper introduces speed breeding, a method that accelerates crop research and breeding by shortening generation times and enabling more generations per year.

Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes.

The paper predicts fluoroquinolone susceptibility in K. pneumoniae using whole genome sequence data and protein abundance measurements from liquid chromatography-tandem mass spectrometry.