Author

T. Heide

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

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Organism:human· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3 Assay:ATAC-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Sottoriva· 5 shared G. D. Cresswell· 5 shared I. Spiteri· 5 shared A.-M. Baker· 4 shared B. Chen· 4 shared C. James· 4 shared C. Kimberley· 4 shared C. Lynn· 4 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

A. Sottoriva

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5 papers

Recent·Most cited

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

E. Lakatos, V. Gunasri, L. Zapata, J. Househam, T. Heide, N. Trahearn, O. Swinyard, L. Cisneros, C. Lynn, M. Mossner, C. Kimberley, I. Spiteri, G. D. Cresswell, G. Llibre-Palomar, M. Mitchison, , T. A. Graham

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

bioRxiv · Feb 12, 2024 · PreprintCancer Biology

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

J. Fernandez-Mateos, S. Milite, E. Oliveira, G. Vlachogiannis, B. Chen, E. Yara, G. D. Cresswell, C. James, L. Patruno, G. Ascolani, A. Acar, T. Heide, I. Spiteri, A. Graudenzi, G. Caravagna, , A. Sottoriva

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

bioRxiv · Nov 15, 2023 · PreprintCancer Biology

Phenotypic plasticity and genetic control in colorectal cancer evolution

J. Househam, T. Heide, G. D. Cresswell, C. Lynn, I. Spiteri, M. Mossner, C. Kimberley, C. Gabbutt, E. Lakatos, A. Berner, M. Schmidt, A.-M. Baker, J. Fernandez-Mateos, B. Chen, L. Zapata, , T. A. Graham

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

The co-evolution of the genome and epigenome in colorectal cancer

T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology