SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches
G. Bertolini, V. Cancila, M. Milione, G. Lo Russo, O. Fortunato, N. Zaffaroni, M. Tortoreto, G. Centonze, C. Chiodoni, F. Facchinetti, F. Giovinazzo, M. Moro, C. Camisaschi, A. De Toma, C. D'Alterio, , L. Roz
This study shows that cisplatin promotes metastasis by creating pro-metastatic niches, which can be blocked by CXCR4 inhibition.
bioRxiv · Oct 26, 2020Cancer Biology