The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies
J. Bohl, M. Moudjou, L. Herzog, F. Reine, F. Sailer, H. Klute, F. Halgand, G. Vand der Rest, Y. Boulard, A. Igel, V. Beringue, H. Rezaei
The paper identifies small infectious prion oligomers that encode the strain structural determinant, showing prion infectivity and SSD are not exclusive to amyloid fibrils.
bioRxiv · Mar 21, 2023Biochemistry