SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine
T. Rothenburger, K.-M. McLaughlin, T. Herold, C. Schneider, T. Oellerich, F. Rothweiler, A. Feber, T. R. Fenton, M. N. Wass, O. Keppler, M. N. Michaelis, J. Cinatl
This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.
bioRxiv · Dec 3, 2019Pharmacology & Toxicology