M. N. Wass

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

Repurposing of the antibiotic nitroxoline for the treatment of mpox

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

Omicron-induced interferon signalling prevents influenza A virus infection

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants

This study evaluates the antiviral efficacy of interferon-beta combined with antiviral drugs against SARS-CoV-2 variants, finding synergistic effects with certain drugs against specific variants.

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

This study shows that SARS-CoV-2 Omicron variants are more sensitive to interferon treatment than Delta variants, suggesting interferons could be effective therapies for Omicron infections.

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates

This study compares drug sensitivity and interferon antagonism between Omicron and Delta SARS-CoV-2 variants, finding similar drug responses but reduced interferon antagonism in Omicron.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Multifaceted roles of SAMHD1 in cancer

This study analyzes SAMHD1's role in cancer using TCGA and TARGET databases, finding no consistent tumour suppressor effect and suggesting context-dependent pro-or anti-tumourigenic effects.

CD47 as a potential biomarker for the early diagnosis of severe COVID-19

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

Data variability in standardised cell culture experiments

The paper analyzes variability in drug response data from standardized cell culture experiments and finds high intrinsic variability even among well-controlled experiments.

COVID-19-related coagulopathy, is transferrin a missing link?

The paper identifies transferrin as a potential coagulation promoter in COVID-19, showing age-related increases, sex differences, and upregulation upon infection.

SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles

This study compares SARS-CoV-2 and SARS-CoV in cell tropism and drug sensitivity, finding differences in conservation, receptor usage, and therapeutic responses to aprotinin and remdesivir.

Drug-adapted cancer cell lines reveal drug-induced heterogeneity and enable the identification of biomarker candidates for the acquired resistance setting

The paper investigates drug-induced heterogeneity in cancer cell lines and identifies biomarkers for acquired resistance to YM155.

Testing of the survivin suppressant YM155 in a large panel of drug-resistant neuroblastoma cell lines

This study tests YM155 in 101 neuroblastoma cell lines, revealing ABCB1 and ABCC1 as mediators of resistance and highlighting cross-resistance differences between drug-adapted lines.

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.

Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.

The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance

This study shows that doxorubicin-loaded human serum albumin nanoparticles enhance anti-cancer activity in drug-resistant neuroblastoma cells by bypassing ABCB1-mediated efflux.

Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity

This study compares the anti-cancer activity of doxorubicin-loaded nanoparticles made from different polymers and preparation methods, finding significant differences in efficacy based on size, drug load, and release kinetics.

Drug repurposing: omeprazole increases the efficacy of acyclovir against herpes simplex virus type 1 and 2

This paper shows that omeprazole enhances acyclovir's effectiveness against herpes simplex virus 1 and 2 in cell cultures without harming cell viability.