Author

T. R. Fenton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Michaelis· 3 shared M. N. Wass· 3 shared A. Feber· 2 shared I. Reddin· 2 shared J. Cinatl· 2 shared K.-M. McLaughlin· 2 shared A. Chakravarthy· 1 shared A. Macdonald· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

M. Michaelis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

H. E. Grimsley, M. Antczak, I. G. Reddin, K.-M. McLaughlin, A. Nist, M. Mernberger, T. Stiewe, T. R. Fenton, D. Speidel, C. Harper-Wynne, K. Cox, J. Cinatl, M. N. Wass, M. Garrett, M. Michaelis

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

bioRxiv · Jan 20, 2024 · PreprintCancer Biology

BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damage

S. C. Baker, A. S. Mason, R. G. Slip, K. T. Skinner, A. Macdonald, O. Masood, R. S. Harris, T. R. Fenton, M. Periyasamy, S. Ali, J. Southgate

This study shows BKPyV infection increases APOBEC3-mediated genomic damage in urothelial cells, contributing to bladder cancer risk in immunocompromised individuals.

bioRxiv · May 13, 2021Cancer Biology

Data variability in standardised cell culture experiments

I. Reddin, T. R. Fenton, M. N. Wass, M. Michaelis

The paper analyzes variability in drug response data from standardized cell culture experiments and finds high intrinsic variability even among well-controlled experiments.

bioRxiv · Feb 27, 2021 · PreprintPharmacology & Toxicology

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

A. Chakravarthy, I. Reddin, S. Henderson, C. Dong, N. Kirkwood, M. Jeyakumar, D. Rothschild Rodriguez, N. Gonzalez Martinez, J. McDermott, X. Su, N. Egawa, C. S. Fjeldbo, V. E. Skingen, M. K. Halle, C. Krakstad, , T. R. Fenton

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

bioRxiv · Apr 2, 2020 · PreprintCancer Biology

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

T. Rothenburger, K.-M. McLaughlin, T. Herold, C. Schneider, T. Oellerich, F. Rothweiler, A. Feber, T. R. Fenton, M. N. Wass, O. Keppler, M. N. Michaelis, J. Cinatl

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.

bioRxiv · Dec 3, 2019Pharmacology & Toxicology