Personalized phosphoproteomics establish mTORC1 as a regulator of exercise-induced insulin sensitization in human skeletal muscle
Magnus R. Leandersson, Hannah Huckstep, Johan Onslev, Nicolai S. Henriksen, Jonas M. Kristensen, M. N. Zankel, R. Elmquist, Joachim Thorup Edberg Madsen, Jakob Solgaard Jensen, Jesper B. Birk, Kim Anker Sjøberg, Tingting Wang, Janni Petersen, Jerry Richard Greenfield, David Ernest James, , Jørgen F. P. Wojtaszewski
The paper uses personalized phosphoproteomics to show that mTORC1 regulates exercise-induced insulin sensitization in human skeletal muscle through a feedback pathway involving MKNK2 and eIF4G1.
bioRxiv · Sep 2, 2026 · PreprintPhysiology