Jørgen F. P. Wojtaszewski

The paper uses personalized phosphoproteomics to show that mTORC1 regulates exercise-induced insulin sensitization in human skeletal muscle through a feedback pathway involving MKNK2 and eIF4G1.

This paper develops a deep learning model to automate glycogen localization in TEM images of skeletal muscle, achieving high accuracy and efficiency compared to manual methods.

This study shows that SIX1 regulates muscle fiber hypertrophy by modulating metabolism and fiber type transitions in response to mechanical overload.

This study develops bioengineered human skeletal muscle tissues that mature metabolically and functionally, capturing key aspects of glucose metabolism and response to exercise and pharmacological agents.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

This study investigates the AMPKgamma3 R225W mutation in human and mouse skeletal muscle, finding no increase in basal activity or glycogen levels, but loss of activation by AICAR/muscle contraction.