Multivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin
A. A. Alnaas, A. Watson-Siriboe, S. Tran, M. Negussie, J. A. Henderson, J. R. Osterberg, N. Lee Chon, J. Oviedo, T. Lyakhova, C. Michel, N. Reisdorph, R. Reisdorph, C. T. Shearn, H. Lin, J. D. Knight
This study shows that the Slp-4 C2A domain binds PIP2 with high affinity through multivalent interactions involving both specific and nonspecific lipid contacts.
bioRxiv · May 29, 2020 · PreprintBiophysics