Author

C. T. Shearn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. A. Alnaas· 1 shared A. Watson-Siriboe· 1 shared B. Thompson· 1 shared C. Michel· 1 shared D. C. Thompson· 1 shared D. J. Orlicky· 1 shared D. W. Nebert· 1 shared E. A. Davidson· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. A. Alnaas

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2 papers

Recent·Most cited

Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype

E. A. Davidson, Y. Chen, S. Singh, D. J. Orlicky, B. Thompson, Y. Wang, G. Charkoftaki, T. Furnary, R. L. Cardone, R. G. Kibbey, C. T. Shearn, D. W. Nebert, D. C. Thompson, V. Vasiliou

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

bioRxiv · Jun 13, 2023 · PreprintPhysiology

Multivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin

A. A. Alnaas, A. Watson-Siriboe, S. Tran, M. Negussie, J. A. Henderson, J. R. Osterberg, N. Lee Chon, J. Oviedo, T. Lyakhova, C. Michel, N. Reisdorph, R. Reisdorph, C. T. Shearn, H. Lin, J. D. Knight

This study shows that the Slp-4 C2A domain binds PIP2 with high affinity through multivalent interactions involving both specific and nonspecific lipid contacts.

bioRxiv · May 29, 2020 · PreprintBiophysics