Differentially accessible Cdc4 phospho-degrons regulate Ctf19CCAN kinetochore subunit stability in mitosis
S. Westermann, M. Böhm, K. Killinger, A. Dudziak, P. Pant, K. Jänen, S. Hohoff, K. Mechtler, M. Örd, M. Loog, E. Sanchez-Garcia
The paper shows that phosphorylation of Cdc4 phospho-degrons on Ame1CENP-U regulates its stability during mitosis by targeting it for degradation, with the Mtw1 complex protecting it from degradation.
bioRxiv · Feb 12, 2021Cell Biology