Spheroid architecture strongly induces miR-221/222 expression and promotes oxidative phosphorylation and survival of mobile tumor cells through a mechanism that includes restriction of miR-9 expression
A. S. Ward, C. N. Hall, M. O. Tree, D. S. Kohtz
This study shows that spheroid architecture increases miR-221/222 expression and OXPHOS activity in ovarian cancer cells, enhancing their survival in nutrient-poor environments.
bioRxiv · Aug 22, 2023 · PreprintCancer Biology